Janumet XR Sitagliptin + Metformin 50/500mg Diabetes Tablets 56s

• Janumet XR 50/500mg Tablets 56 Tablets pack of 56 extended-release film-coated tablets • Helps control blood sugar levels in adults with type 2 diabetes mellitus • Contains sitagliptin 50mg + metformin hydrochloride 500mg in extended-release form • Once-daily dosing with improved gastrointestinal tolerability compared to immediate-release metformin • Suitable for adults with type 2 diabetes inadequately controlled on metformin alone or other therapies (as prescribed)

Janumet XR 50/500mg Tablets 56 Tablets is an extended-release combination oral antidiabetic medication that combines two proven agents: sitagliptin (a DPP-4 inhibitor) and metformin hydrochloride (a biguanide). Sitagliptin enhances incretin hormones (GLP-1 and GIP), increasing insulin release and decreasing glucagon secretion in a glucose-dependent manner, while metformin reduces hepatic glucose production, decreases intestinal glucose absorption and improves insulin sensitivity. The extended-release (XR) formulation allows once-daily dosing and releases metformin more slowly, reducing gastrointestinal side effects (e.g., nausea, diarrhea) commonly associated with immediate-release metformin. It is indicated as an adjunct to diet and exercise to improve glycemic control in adults with type 2 diabetes when treatment with both sitagliptin and metformin is appropriate. The 56-tablet pack provides a 2-month supply (once daily), making it convenient for long-term management. Tablets are film-coated for easier swallowing and should not be split, crushed or chewed to preserve the extended-release mechanism. Benefits: • Provides dual-action glucose control (increases insulin, decreases glucagon & hepatic glucose) • Once-daily dosing for better convenience and adherence • Extended-release metformin improves GI tolerability • Helps lower HbA1c and fasting plasma glucose effectively • No increased risk of hypoglycemia when used alone (low risk overall) How to Use: • Adults: Take 1 tablet once daily with a meal (preferably evening meal) or as advised by a healthcare professional • Swallow whole with water – do not split, crush, chew or dissolve • Do not exceed 1 tablet per day • Take consistently at the same time daily • Monitor blood glucose regularly as directed by your doctor • Do not exceed the recommended dosage • Consult a doctor before use if pregnant, nursing, have kidney/liver issues, heart failure, metabolic acidosis, or taking other medicines (especially diuretics, NSAIDs, alcohol)